Uptake of Aristolochic Acid I into Caco-2 Cells by Monocarboxylic Acid Transporters
نویسندگان
چکیده
منابع مشابه
Fatty acid uptake by Caco-2 human intestinal cells.
The Caco-2 human enterocytic cell line was used to study the kinetics and mechanism of intestinal long chain fatty acid uptake. Initial rates of palmitate (16:0), oleate (18:1), and octanoate (8:0) uptake were determined for adherent cells at greater than 7 days confluence. Uptake of long chain 18:1 and 16:0 by cells grown on coverslips was saturable with an apparent Km of 0.3 microM, but also ...
متن کاملTransepithelial transport of ferulic acid by monocarboxylic acid transporter in Caco-2 cell monolayers.
Our previous study (Biosci. Biotechnol. Biochem., 66, 2449-2457 (2002)), suggested that ferulic acid was transported via a monocarboxylic acid transporter (MCT). Transepithelial transport of ferulic acid was examined in this study by directly measuring the rate of its transport across Caco-2 cell monolayers. Ferulic acid transport was dependent on pH, and in a vectorical way in the apical-basol...
متن کاملUptake and metabolism of structured triglyceride by Caco-2 cells: reversal of essential fatty acid deficiency.
Structured lipids have been proposed as efficient vehicles for the supplementation of essential fatty acids (EFA) to patients with malabsorption. We investigated how a novel structured triglyceride (STG), containing purely octanoic acid in the sn-1/ sn-3 and [14C]linoleic acid in the sn-2 positions, was incorporated into different lipid classes in Caco-2 cells. We also evaluated the contributio...
متن کاملCommon mechanisms of monoacylglycerol and fatty acid uptake by human intestinal Caco-2 cells.
Free fatty acids (FFA) and sn-2-monoacylglycerol (sn-2-MG), the two hydrolysis products of dietary triacylglycerol, are absorbed from the lumen into polarized enterocytes that line the small intestine. Intensive studies regarding FFA transport across the brush-border membrane of the enterocyte are available; however, little is known about sn-2-MG transport. We therefore studied the kinetics of ...
متن کاملMonocarboxylic acid transport.
Monocarboxylates such as lactate, pyruvate, and the ketone bodies play major roles in metabolism and must be transported across both the plasma membrane and mitochondrial inner membrane. A family of five proton-linked MonoCarboxylate Transporters (MCTs) is involved in the former and the mitochondrial pyruvate carrier (MPC) mediates the latter. In the intestine and kidney, two Sodium-coupled Mon...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2014
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.b14-00219